DSIP (delta sleep-inducing peptide) is a nine-amino-acid peptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.[1] Its international nonproprietary name is emideltide.[6] Pepitiva supplies DSI...
Certificate of Analysis included with every order.
Technical Specifications
Purity
≥98%
Form
Lyophilized Powder
Storage
-20°C
Molecular Weight
848.8 g/mol
Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
CAS Number
62568-57-4
About DSIP
DSIP (delta sleep-inducing peptide) is a nine-amino-acid peptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.[1] Its international nonproprietary name is emideltide.[6] Pepitiva supplies DSIP as a lyophilized powder (5 mg vials, ≥98% purity) for in vitro and preclinical research.
DSIP was isolated in 1977 by the Schoenenberger-Monnier group in Basel from the cerebral venous blood of rabbits.[2] When infused into the brain ventricles of rabbits, the synthetic nonapeptide enhanced slow-wave (delta) and spindle EEG patterns, which gave the peptide its name.[1]
For research use only. Not for human consumption.
Quality & Storage
≥98% purity. Lyophilized Powder. Storage: -20°C. For research purposes only.
Mechanism of Action
An unresolved mechanism
Almost five decades after its discovery, DSIP's biology is still unclear. No gene, precursor protein or receptor for DSIP has been isolated, and a 2006 review described the hypothesis of DSIP as a sleep factor as "extremely poorly documented and still weak."[2] Its structure does not resemble any other known peptide family.[2]
What has been observed
EEG effects in rabbits: only the full synthetic nonapeptide, and not its fragments or analogs tested, specifically enhanced delta and spindle EEG activity.[1]
DSIP-like immunoreactivity: the material detected by DSIP antibodies is concentrated in neurosecretory nuclei of the hypothalamus, which led the reviewers to propose that a related, still unidentified DSIP-like peptide may exist.[2]
Research Applications
Human sleep studies
Small controlled studies of DSIP in chronic insomnia were run in the 1980s and early 1990s, with modest or negative results:
In a double-blind crossover study with polysomnography, total sleep time rose with DSIP, but the authors concluded that the sleep improvement was of little clinical significance.[3]
In a double-blind study in 16 chronic insomniac patients, effects on sleep efficiency and latency were weak and partly explained by changes in the placebo group; the authors concluded that short-term DSIP was not likely to be of major therapeutic benefit.[4]
DSIP is not approved as a medicine by the FDA or the European Medicines Agency.
Preclinical findings
Experimental stroke: in rats with middle cerebral artery occlusion, intranasal DSIP over 8 days was associated with faster recovery on the rotarod motor test; the reduction in infarct size was not statistically significant.[5]
Laboratory research applications
Sleep and EEG research: slow-wave and spindle activity in animal models.
Neuroendocrine studies: DSIP-like immunoreactivity in the hypothalamus.
This product is sold for laboratory research only.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
What is DSIP peptide?
Delta sleep-inducing peptide, a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated from rabbit blood in 1977. Its INN is emideltide.
Does DSIP improve sleep?
It enhanced delta EEG activity in rabbits. In small double-blind studies in people with chronic insomnia, effects were weak, and the authors judged them of little clinical significance.
What is the DSIP mechanism of action?
It is unknown. No gene, precursor or receptor for DSIP has been identified, and its role as a natural sleep factor remains unproven.
Is DSIP approved by the FDA?
No. DSIP is not an approved medicine in the US or the EU. It is sold here for laboratory research only.
What is the molecular weight of DSIP?
848.8 g/mol (formula C35H48N10O15), CAS 62568-57-4, according to PubChem.
How should DSIP be stored?
Keep the lyophilized powder at −20 °C, protected from light and moisture.
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
Scientific References
Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977;74(3):1282-1286. PubMed
Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006;97(2):303-309. PubMed
Monti JM, Debellis J, Alterwain P, et al. Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs. Int J Clin Pharmacol Res. 1987;7(2):105-110. PubMed
Bes F, Hofman W, Schuur J, et al. Effects of delta sleep-inducing peptide on sleep of chronic insomniac patients. A double-blind study. Neuropsychobiology. 1992;26(4):193-197. PubMed
Tukhovskaya EA, Ismailova AM, Shaykhutdinova ER, et al. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules. 2021;26(17):5173. PubMed
Sources are peer-reviewed publications indexed in PubMed and trial registrations on ClinicalTrials.gov. Each citation was checked against its PubMed record.
For research use only. Not for human consumption.
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