Epithalon
Telomerase-activating peptide for longevity research.
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥98% |
|---|---|
| Form | Lyophilized powder |
| Storage | -20°C |
| Molecular Weight | 390.35 Da |
| Sequence | Ala-Glu-Asp-Gly |
| CAS Number | 307297-39-8 |
About This Peptide
Epithalon (Epitalon) is a synthetic tetrapeptide based on the natural peptide epithalamin produced by the pineal gland. Research has focused on its ability to activate telomerase, the enzyme responsible for maintaining telomere length, making it a key compound in aging and longevity research.
Research Applications
Telomerase activation, telomere length studies, pineal gland function, cellular aging research.
Mechanism of Action
Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on the natural peptide epithalamin, which is produced by the pineal gland. Epithalon has been shown to activate telomerase, the ribonucleoprotein enzyme responsible for adding telomeric repeat sequences (TTAGGG) to chromosome ends. Telomere shortening is a fundamental mechanism of cellular aging, and telomerase activation can extend the replicative capacity of somatic cells. Additionally, Epithalon modulates melatonin production by the pineal gland and influences the neuroendocrine regulation of aging processes.
Research Applications
Epithalon is used in research focused on telomere biology, cellular aging, and longevity mechanisms. Key applications include studies of telomerase regulation and activation, telomere length dynamics in different cell types, replicative senescence and the Hayflick limit, pineal gland function and melatonin synthesis, and neuroendocrine aging. Epithalon is also employed in comparative longevity studies examining the relationship between telomere maintenance and organism lifespan in various model systems.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.
