GLOW is a lyophilized research blend that combines three peptides studied in tissue-repair models in a single 70 mg vial: GHK-Cu (50 mg), TB-500 (10 mg) and BPC-157 (10 mg), at ≥98% purity. It is inte...
GLOW is a lyophilized research blend that combines three peptides studied in tissue-repair models in a single 70 mg vial: GHK-Cu (50 mg), TB-500 (10 mg) and BPC-157 (10 mg), at ≥98% purity. It is intended for laboratory studies that look at these compounds together.
What is in the blend
GHK-Cu (50 mg): the copper complex of the plasma tripeptide glycyl-L-histidyl-L-lysine. In fibroblast cultures it stimulates collagen synthesis and matrix metalloproteinase-2 expression.[1][2]
TB-500 (10 mg): a synthetic peptide based on thymosin beta-4 (Tβ4), an actin-binding protein. In a rat full-thickness wound model, Tβ4 increased re-epithelialization, collagen deposition and angiogenesis.[5]
BPC-157 (10 mg): a 15-amino-acid peptide (GEPPPGKPADDAGLV) based on a gastric juice protein. In cell and animal studies it promoted tendon fibroblast migration and angiogenesis through VEGFR2.[3][4]
Evidence for the combination
Each component has its own published literature, but we found no published experimental study that tests this three-peptide combination. Any interaction between them, additive or otherwise, is an open research question rather than an established effect.
For research use only. Not for human consumption.
Quality & Storage
≥98% purity. Lyophilized powder. Storage: -20°C. For research purposes only.
Mechanism of Action
The three components act through different, partly overlapping pathways, which is the rationale for studying them together:
Extracellular matrix (GHK-Cu): collagen synthesis in fibroblasts began at 10⁻¹² to 10⁻¹¹ M and peaked at 10⁻⁹ M; GHK-Cu also raised MMP-2 with its inhibitors TIMP-1 and TIMP-2, an effect that depended on the copper.[1][2]
Cell migration and survival (Tβ4): Tβ4 stimulated keratinocyte migration 2- to 3-fold in vitro, and in the heart it formed a complex with PINCH and integrin-linked kinase that activated the survival kinase Akt.[5][6]
Angiogenesis (BPC-157 and Tβ4): BPC-157 increased VEGFR2 expression and activated VEGFR2-Akt-eNOS signaling in endothelial cells, and Tβ4 stimulated coronary vessel formation and epicardial progenitor outgrowth in mice.[4][7]
Tendon fibroblasts (BPC-157): faster outgrowth from explants, better survival under oxidative stress and dose-dependent migration through the FAK-paxillin pathway.[3]
Research Applications
Laboratory research applications
Wound-healing models: re-epithelialization, collagen deposition and angiogenesis, with each component tested alone and in combination.
Fibroblast and keratinocyte assays: migration, matrix synthesis and remodeling.
Angiogenesis assays: endothelial tube formation and VEGFR2 signaling.
Combination design: because the blend fixes the ratio (5:1:1 by mass), controlled studies usually include each single peptide as a comparator: GHK-Cu, BPC-157 and TB-500, or the two-peptide BPC-157 + TB-500.
Related blends
KLOW contains the same three peptides plus 10 mg of KPV, a tripeptide studied for anti-inflammatory activity in intestinal inflammation models.[8]
This product is sold for laboratory research and is not intended for human or veterinary use.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
What is in the GLOW peptide blend?
Each 70 mg vial contains GHK-Cu 50 mg, TB-500 10 mg and BPC-157 10 mg, lyophilized together at ≥98% purity.
What is the difference between GLOW and KLOW?
KLOW contains the same three peptides as GLOW plus 10 mg of KPV, for 80 mg per vial. See KLOW.
Has the GLOW combination been studied?
Each component has published preclinical research, but we found no published experimental study that tests this specific three-peptide combination. Interactions between the components are an open research question.
Keep the lyophilized powder at −20 °C, protected from light and moisture.
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
Scientific References
Maquart FX, Pickart L, Laurent M, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343-346. PubMed
Siméon A, Emonard H, Hornebeck W, Maquart FX. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000;67(18):2257-2265. PubMed
Chang CH, Tsai WC, Lin MS, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. PubMed
Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333. PubMed
Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. PubMed
Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. PubMed
Smart N, Risebro CA, Melville AA, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-182. PubMed
Sources are peer-reviewed publications indexed in PubMed and trial registrations on ClinicalTrials.gov. Each citation was checked against its PubMed record.
For research use only. Not for human consumption.
Related Peptides
Exclusive≥98%
Regeneration
KLOW (GHK-Cu + TB-500 + BPC-157 + KPV)
KLOW is a lyophilized research blend of four peptides in a single 80 mg vial: GHK-Cu (50 mg), TB-500...
