KLOW is a lyophilized research blend of four peptides in a single 80 mg vial: GHK-Cu (50 mg), TB-500 (10 mg), BPC-157 (10 mg) and KPV (10 mg), at ≥98% purity. It contains the three peptides of GLOW pl...
KLOW is a lyophilized research blend of four peptides in a single 80 mg vial: GHK-Cu (50 mg), TB-500 (10 mg), BPC-157 (10 mg) and KPV (10 mg), at ≥98% purity. It contains the three peptides of GLOW plus the anti-inflammatory tripeptide KPV.
What is KLOW?
GHK-Cu (50 mg): the copper complex of the plasma tripeptide Gly-His-Lys. It stimulates collagen synthesis and MMP-2 expression in fibroblast cultures.[1][2][12]
TB-500 (10 mg): a synthetic peptide based on thymosin beta-4 (Tβ4), an actin-binding protein that promoted re-epithelialization and angiogenesis in a rat wound model.[5]
BPC-157 (10 mg): a 15-amino-acid peptide (GEPPPGKPADDAGLV) studied for tendon fibroblast migration and VEGFR2-dependent angiogenesis.[3][4][13]
KPV (10 mg): Lys-Pro-Val, the C-terminal tripeptide of α-MSH, which reduced inflammation in mouse colitis models.[8][9][14]
Evidence for the combination
We found no published experimental study of this four-peptide blend. The only combination data we found involve two of its components: in a 2026 rat Achilles tendon study, BPC-157 plus TB-500 did not add benefit over either peptide alone.[11] How the four components interact remains an open research question.
For research use only. Not for human consumption.
Quality & Storage
≥98% purity. Lyophilized powder. Storage: -20°C. For research purposes only.
Mechanism of Action
KLOW brings together four peptides that act on different steps of tissue repair:
Matrix production and remodeling (GHK-Cu): in fibroblasts, collagen synthesis started at 10⁻¹² to 10⁻¹¹ M and peaked at 10⁻⁹ M, and GHK-Cu raised MMP-2 together with its inhibitors TIMP-1 and TIMP-2, a copper-dependent effect.[1][2]
Cell migration and survival (Tβ4): Tβ4 increased keratinocyte migration 2- to 3-fold in vitro and, in heart tissue, activated the survival kinase Akt through a complex with PINCH and integrin-linked kinase.[5][6]
New blood vessels (BPC-157 and Tβ4): BPC-157 raised VEGFR2 expression and activated VEGFR2-Akt-eNOS signaling in endothelial cells; Tβ4 drove coronary vessel formation and epicardial progenitor outgrowth in mice.[4][7]
Tendon fibroblasts (BPC-157): faster explant outgrowth, better survival under oxidative stress and dose-dependent migration via FAK-paxillin.[3]
Inflammatory signaling (KPV): KPV enters intestinal and immune cells through the PepT1 transporter and inhibits NF-κB and MAP kinase signaling at nanomolar concentrations; in airway epithelial cells it blocked nuclear import of the NF-κB subunit p65.[8][10]
Research Applications
Laboratory research applications
Repair under inflammation: wound and tissue-injury models where both matrix repair and inflammatory signaling are measured.
Fibroblast, keratinocyte and endothelial assays: migration, matrix synthesis and tube formation.
NF-κB and cytokine readouts: the KPV component adds an anti-inflammatory arm to the GLOW set.[8][9]
Combination design: the blend fixes the mass ratio at 5:1:1:1, so controlled studies usually include single-peptide comparators (GHK-Cu, TB-500, BPC-157, KPV) and the three-peptide GLOW blend to isolate the effect of KPV.
Related products
BPC-157 + TB-500 combines two of the four peptides, and AHK-Cu is a related copper tripeptide.
None of these peptides is approved for human or veterinary use. This product is sold for laboratory research only.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
What is KLOW?
KLOW is a research blend of four peptides lyophilized together: GHK-Cu 50 mg, TB-500 10 mg, BPC-157 10 mg and KPV 10 mg, for 80 mg per vial at ≥98% purity.
What is the difference between KLOW and GLOW?
GLOW contains GHK-Cu, TB-500 and BPC-157 (70 mg per vial). KLOW has the same three peptides plus 10 mg of KPV. See GLOW.
What does KPV add to the blend?
KPV is the C-terminal tripeptide of α-MSH. In cell and mouse studies it inhibited NF-κB inflammatory signaling and reduced colitis. See KPV.
Has the KLOW combination been studied?
We found no published experimental study of this four-peptide combination. In a 2026 rat tendon study, combining two of its components, BPC-157 and TB-500, gave no extra benefit over either one alone.
Keep the lyophilized powder at −20 °C, protected from light and moisture.
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
Scientific References
Maquart FX, Pickart L, Laurent M, et al. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988;238(2):343-346. PubMed
Siméon A, Emonard H, Hornebeck W, Maquart FX. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000;67(18):2257-2265. PubMed
Chang CH, Tsai WC, Lin MS, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. PubMed
Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333. PubMed
Malinda KM, Sidhu GS, Mani H, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999;113(3):364-368. PubMed
Bock-Marquette I, Saxena A, White MD, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004;432(7016):466-472. PubMed
Smart N, Risebro CA, Melville AA, et al. Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature. 2007;445(7124):177-182. PubMed
Kannengiesser K, Maaser C, Heidemann J, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324-331. PubMed
Land SC. Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: mechanism of KPV action and a role for MC3R agonists. Int J Physiol Pathophysiol Pharmacol. 2012;4(2):59-73. PubMed
Biçer O, Adanir O, Güleryüz Y, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg. 2026;37(3):822-837. PubMed
Sources are peer-reviewed publications indexed in PubMed and trial registrations on ClinicalTrials.gov. Each citation was checked against its PubMed record.
For research use only. Not for human consumption.
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