MOTS-c
Mitochondrial peptide for cellular metabolism research.
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥98% |
|---|---|
| Form | Lyophilized powder |
| Storage | -20°C |
| Molecular Weight | 2174.69 Da |
| Sequence | MRWQEMGYIFYPRKLR |
| CAS Number | 1627580-64-6 |
About This Peptide
MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA gene. It regulates metabolic homeostasis by targeting the AMPK pathway. Research has shown its role in insulin sensitivity, exercise mimetic effects, and protection against age-dependent and diet-induced metabolic dysfunction.
Research Applications
Mitochondrial function, AMPK pathway activation, metabolic homeostasis, exercise physiology research.
Mechanism of Action
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-c) is a mitochondria-derived peptide encoded within the mitochondrial genome. This 16-amino acid peptide activates AMPK (AMP-activated protein kinase), a master regulator of cellular energy metabolism, and modulates the folate-methionine cycle affecting cellular methylation patterns. MOTS-c translocates to the cell nucleus in response to metabolic stress, where it directly regulates nuclear gene expression related to antioxidant defense, glucose metabolism, and cellular stress response pathways.
Research Applications
MOTS-c is used in cutting-edge research on mitochondrial-derived peptides, cellular energy homeostasis, AMPK signaling, and exercise mimetic mechanisms. Research applications include studies of mitochondrial-nuclear communication, metabolic stress response, insulin sensitivity regulation, and cellular aging mechanisms. MOTS-c has emerged as a key research tool in the study of exercise biology, as it has been identified as an exercise-induced factor that mediates some of the metabolic benefits of physical activity.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.
