NAD+
Essential coenzyme for cellular longevity research.
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥98% |
|---|---|
| Form | Lyophilized powder |
| Storage | -20°C |
| Molecular Weight | 663.43 Da |
| Sequence | C₂₁H₂₇N₇O₁₄P₂ |
| CAS Number | 53-84-9 |
About This Peptide
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in all living cells. It plays a critical role in cellular energy metabolism, DNA repair via sirtuins and PARPs, and circadian rhythm regulation. Declining NAD+ levels are associated with aging and age-related metabolic disorders.
Research Applications
Sirtuin activation, PARP-mediated DNA repair, cellular energy metabolism, NAD+/NADH ratio studies, aging models.
Mechanism of Action
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every living cell, serving as a critical electron carrier in metabolic redox reactions including glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond its role in energy metabolism, NAD+ serves as a substrate for sirtuin enzymes (SIRT1-7), which regulate gene expression, DNA repair, circadian rhythms, and inflammatory responses. NAD+ is also consumed by poly(ADP-ribose) polymerases (PARPs) during DNA damage repair and by CD38 ectoenzyme in immune cell signaling.
Research Applications
NAD+ is a fundamental research tool in studies of cellular metabolism, aging biology, and epigenetic regulation. Applications include investigation of sirtuin-dependent pathways, PARP-mediated DNA repair mechanisms, mitochondrial biogenesis, circadian rhythm regulation, and immune cell metabolism. NAD+ decline is a hallmark of aging, making it a key compound in geroscience research examining the relationship between NAD+ homeostasis, cellular senescence, and age-related functional decline.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.
