Cerebrolysin
Cerebrolysin is a neuroprotective peptide complex derived from purified porcine brain proteins, containing a standardized low-molecular-weight neurotrophic peptide fraction. It mimics the biological a...
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥98% |
|---|---|
| Form | Lyophilized Powder |
| Storage | -20°C |
| Molecular Weight | Complex mixture; peptide fraction 1,000–10,000 Da (~25% active neurotrophic fraction) |
| Sequence | Complex neuropeptide mixture derived from porcine brain proteolysis; BDNF/NGF/CNTF/GDNF-like neurotrophic activity |
| CAS Number | 12629-09-3 |
About This Peptide
Cerebrolysin is a neuroprotective peptide complex derived from purified porcine brain proteins, containing a standardized low-molecular-weight neurotrophic peptide fraction. It mimics the biological activity of endogenous neurotrophic factors including BDNF, NGF, CNTF, and GDNF, supporting neuronal survival, synaptic plasticity, and neuroprotection research across multiple CNS disease models.
Research Applications
≥98% purity. Lyophilized Powder. Storage: -20°C. For research purposes only.
Mechanism of Action
Cerebrolysin is a standardized neuropeptide complex produced by controlled enzymatic proteolysis of porcine brain proteins. Its active peptide fraction (MW < 10,000 Da) accounts for approximately 25% of the total composition, with the remaining 75% comprising free amino acids that serve as substrates for neurotransmitter biosynthesis. The neurotrophic peptide fraction mimics the biological activity of endogenous growth factors including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF), and glial cell line-derived neurotrophic factor (GDNF). These bioactive peptides activate receptor tyrosine kinase signaling cascades, specifically engaging TrkB (the high-affinity BDNF receptor) and TrkA (the NGF receptor), initiating downstream pathways including MAPK/ERK (promoting neuronal differentiation and survival), PI3K/Akt (anti-apoptotic, supporting mitochondrial membrane integrity), and PLCγ (regulating synaptic plasticity and long-term potentiation). Additionally, Cerebrolysin attenuates tau hyperphosphorylation by modulating CDK5 and GSK-3β kinase activity, inhibits amyloid-beta peptide aggregation and neurotoxicity, reduces excitotoxic glutamate damage through NMDA receptor downregulation, and activates endogenous antioxidant defense systems (SOD, catalase), collectively producing a multi-target neuroprotective and neuroregenerative profile.
Research Applications
Cerebrolysin is extensively used in preclinical and translational neuroscience research investigating neuroprotective strategies and neurodegenerative disease mechanisms. Primary research applications include Alzheimer's disease models, where it has demonstrated reduction in amyloid-beta plaque burden, tau hyperphosphorylation, and neuroinflammatory markers (IL-1β, TNF-α) in transgenic rodent studies. In cerebrovascular research, Cerebrolysin is employed to study ischemic stroke recovery, penumbra tissue salvage, post-stroke neuroplasticity, and adult neurogenesis in the hippocampal dentate gyrus and subventricular zone. Traumatic brain injury (TBI) research utilizes Cerebrolysin to investigate secondary injury cascades, axonal regeneration pathways, and cognitive outcome restoration in controlled cortical impact models. Additional research applications include vascular dementia and multi-infarct cognitive decline models, Parkinson's disease neuroprotection studies (dopaminergic neuron survival), and investigations of synaptogenesis and dendritic spine density. Researchers also employ Cerebrolysin in comparative studies against recombinant BDNF and NGF to characterize relative potency, receptor binding profiles, and mechanistic overlap. Its multi-factorial neurotrophic, anti-amyloidogenic, anti-apoptotic, and anti-excitotoxic profile makes it a comprehensive reference compound for neuroprotection and cognitive neuroscience research programs.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.