SLU-PP-332 is a synthetic small molecule that activates the estrogen-related receptors ERRα, ERRβ and ERRγ, with the highest potency for ERRα.[1] It is not a peptide: chemically it is an acylhydrazone...
Certificate of Analysis included with every order.
Technical Specifications
Purity
≥98%
Form
Lyophilized powder
Storage
-20°C
Molecular Weight
290.3 g/mol
Sequence
—
CAS Number
303760-60-3
About SLU-PP-332
SLU-PP-332 is a synthetic small molecule that activates the estrogen-related receptors ERRα, ERRβ and ERRγ, with the highest potency for ERRα.[1] It is not a peptide: chemically it is an acylhydrazone, 4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide.[6] Pepitiva supplies SLU-PP-332 as a powder (5 mg vials, ≥98% purity) for in vitro and preclinical research.
Key identifiers
Chemical name: 4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide
Researchers in St. Louis, Missouri, and collaborating institutes reported SLU-PP-332 in 2023 as an ERR agonist with pharmacokinetic properties suitable for use in animals, and showed that it switched on a genetic program similar to that of acute aerobic exercise in mice.[1] All published efficacy data come from cell and mouse studies.[1][2][3]
For research use only. Not for human consumption.
Quality & Storage
≥98% purity. Lyophilized powder. Storage: -20°C. For research purposes only.
Mechanism of Action
Estrogen-related receptors
ERRs are orphan nuclear receptors (no natural ligand is known) that regulate energy metabolism. Genetic studies link them to skeletal muscle exercise capacity, and before SLU-PP-332 few synthetic ERR agonists could be used in vivo.[1]
Reported effects
Muscle cells: SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line.[1]
Mice: it increased type IIa oxidative muscle fibers and exercise endurance, and ERRα activation was required for the endurance effect.[1]
Gene programs: in the heart, ERR agonists activated genes for fatty acid metabolism and mitochondrial function, with ERRγ as the main mediator.[3]
Research Applications
Preclinical findings
Obesity and metabolic syndrome: in diet-induced obese and ob/ob mice, SLU-PP-332 increased energy expenditure and fatty acid oxidation, decreased fat mass accumulation and improved insulin sensitivity.[2]
Heart failure: in a mouse pressure-overload model, SLU-PP-332 and the related compound SLU-PP-915 improved ejection fraction, reduced fibrosis and increased survival.[3]
Regulatory and conflict-of-interest notes
SLU-PP-332 is an early-stage research compound; it is not approved for any use and has no published clinical trials. Several of its developers declared stock in a company focused on ERR-based therapeutics.[1] The World Anti-Doping Agency prohibits exercise mimetics and metabolic modulators, and anti-doping laboratories have already characterized SLU-PP-332 metabolites to detect misuse.[4][5]
Laboratory research applications
Nuclear receptor pharmacology: ERRα, ERRβ and ERRγ activation assays.
Mitochondrial and metabolic studies: respiration, fatty acid oxidation and oxidative fiber typing.
Analytical method development: LC-HRMS detection of the parent compound and its phase I and II metabolites.[4][5]
Comparison studies: with mitochondria-related compounds such as MOTS-c and NAD+.
This product is sold for laboratory research only.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
What is SLU-PP-332?
A synthetic small-molecule agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ, described in 2023 as an exercise mimetic in mice.
Is SLU-PP-332 a peptide?
No. It is a small organic molecule (formula C18H14N2O2, 290.3 g/mol), an acylhydrazone, not a chain of amino acids.
How does SLU-PP-332 work?
It activates ERRs, nuclear receptors that control mitochondrial and fatty acid metabolism. In mice it induced an acute aerobic exercise gene program that depended on ERRα.
Has SLU-PP-332 been tested in humans?
No clinical trials have been published. The available data come from cell cultures and mice.
Is SLU-PP-332 banned in sports?
The World Anti-Doping Agency prohibits exercise mimetics and metabolic modulators, and anti-doping laboratories have published methods to detect SLU-PP-332 metabolites.
How should SLU-PP-332 be stored?
Keep the powder at −20 °C, protected from light and moisture.
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
Scientific References
Billon C, Sitaula S, Banerjee S, et al. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023;18(4):756-771. PubMed
Billon C, Schoepke E, Avdagic A, et al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2024;388(2):232-240. PubMed
Xu W, Billon C, Li H, et al. Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function. Circulation. 2024;149(3):227-250. PubMed
Avliyakulov NK, Sobolevsky T, Ahrens E. Analysis and Identification of In Vitro Metabolites of Exercise Mimetic SLU-PP-332 ERRα/β/γ Agonist for Doping-Control Purposes. Drug Test Anal. 2026;18(3):439-450. PubMed
Möller T, Krug O, Thevis M. In Vitro Metabolism and Analytical Characterization of SLU-PP-332 and SLU-PP-915: Novel Pan-ERR Agonists With Doping Potential. Rapid Commun Mass Spectrom. 2026;40(8):e70039. PubMed
PubChem. SLU-PP-332, CID 5338394: C18H14N2O2, 290.3 g/mol; CAS 303760-60-3. Source
Sources are peer-reviewed publications indexed in PubMed and trial registrations on ClinicalTrials.gov. Each citation was checked against its PubMed record.
For research use only. Not for human consumption.
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