BPC-157
BPC-157 (Body Protection Compound-157), catalogued under internal code BPC-157, is a synthetic pentadecapeptide comprising 15 amino acids derived from a partial sequence of human gastric juice protein...
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥99% |
|---|---|
| Form | Lyophilized Powder |
| Storage | -20°C |
About This Peptide
BPC-157 (Body Protection Compound-157), catalogued under internal code BPC-157, is a synthetic pentadecapeptide comprising 15 amino acids derived from a partial sequence of human gastric juice protein. With the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, it is classified as a stable gastric peptide fragment and has attracted considerable attention in preclinical research owing to its remarkable stability in biological fluids compared with its parent protein. The compound is supplied as a lyophilized powder of ≥99% purity, formulated to support reproducible in vitro and in vivo experimental work.
BPC-157 has become a subject of substantial scientific interest primarily because of its apparent pleiotropic activity across multiple tissue and organ systems in animal models. Investigations dating back to the early 1990s have explored its effects on gastrointestinal mucosal integrity, musculoskeletal tissue repair, and angiogenic signaling cascades in rodent studies. Researchers have examined BPC-157 in the context of wound-healing biology, soft-tissue regeneration models, and nitric oxide pathway modulation, making it a versatile tool compound in pharmacological and physiological research programs.
Structurally, BPC-157 belongs to the broader class of endogenous peptide fragments that exhibit cytoprotective properties in experimental settings. Its resistance to enzymatic degradation in gastric and intestinal environments renders it particularly useful for studies requiring sustained peptide activity under physiological conditions. As a result, BPC-157 is frequently employed in model systems where peptide stability is a critical experimental variable. Researchers studying growth factor receptor interactions, cytoskeletal reorganization, and connective tissue biology have incorporated BPC-157 as a reference or probe compound in mechanistic assays.
For research use only. Not for human consumption. All data pertaining to BPC-157 referenced here derive from peer-reviewed preclinical literature; no clinical efficacy or therapeutic utility is implied or should be inferred.
Research Applications
≥99% purity. Lyophilized Powder. Storage: -20°C. For research purposes only.
Mechanism of Action
At the molecular level, BPC-157 has been reported in preclinical studies to interact with components of the nitric oxide (NO) signaling axis, modulating endothelial nitric oxide synthase (eNOS) expression and NO production in vascular and mucosal cell models. This interaction is thought to underpin observations of enhanced microvascular network formation in in vivo angiogenesis assays, with BPC-157 appearing to upregulate vascular endothelial growth factor receptor 2 (VEGFR2) signaling and promote endothelial cell migration and tube formation in culture.
Additional mechanistic investigations have implicated BPC-157 in the modulation of the FAK-paxillin pathway, a key regulator of focal adhesion dynamics and cytoskeletal organization. In fibroblast and tendon cell culture models, treatment with BPC-157 has been associated with increased phosphorylation of focal adhesion kinase (FAK) and downstream activation of Rac1/Cdc42 GTPases, facilitating actin cytoskeleton remodeling relevant to cell motility and extracellular matrix remodeling studies. The compound also appears to interact with the growth hormone receptor signaling cascade, with data from rodent models suggesting upregulation of GH receptor expression in injured tissues, potentially linking BPC-157 activity to IGF-1-mediated tissue maintenance pathways under experimental conditions.
Research Applications
BPC-157 is utilized across a range of in vitro and preclinical in vivo research contexts. Representative application areas include:
- Gastrointestinal mucosal biology: Investigating cytoprotective mechanisms in gastric and intestinal epithelial cell cultures exposed to chemical or oxidative insult.
- Angiogenesis and vascular biology models: Studying endothelial cell tube formation, migration assays, and VEGFR2-mediated signaling in 2D and 3D culture systems.
- Tendon and connective tissue repair research: Examining fibroblast proliferation, collagen synthesis, and FAK pathway activation in preclinical musculoskeletal injury models.
- Nitric oxide pathway modulation: Probing eNOS expression and NO bioavailability in vascular and mucosal tissue preparations.
- Neuroprotection and neuronal cell studies: Assessing neurotrophic and neuroprotective responses in primary neuronal cultures and rodent central nervous system injury models.
- Growth factor receptor interaction studies: Characterizing interactions with GH and IGF-1 receptor pathways in cell-based assays and tissue explant models.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.