MIC Blend combines three compounds known as lipotropes: methionine, inositol and choline. Lipotropes are substances shown in animal studies to hasten the removal of fat from the liver or to reduce hep...
Certificate of Analysis included with every order.
About MIC Blend
MIC Blend combines three compounds known as lipotropes: methionine, inositol and choline. Lipotropes are substances shown in animal studies to hasten the removal of fat from the liver or to reduce hepatic fat deposition.[1] Pepitiva supplies MIC Blend as a lyophilized powder (2160 mg vials, ≥98% purity) for in vitro and preclinical research.
What is in the blend
L-Methionine (C5H11NO2S, 149.21 g/mol): an essential sulfur amino acid; the enzyme methionine adenosyltransferase uses it to make S-adenosylmethionine (SAM), the main methyl donor.[2][9]
Inositol (myo-inositol, C6H12O6, 180.16 g/mol): a cyclic sugar alcohol classed among the main lipotropes.[1][10]
Choline (cation C5H14NO+, 104.17 g/mol): a nutrient needed for methyl donation, membrane function and neurotransmission.[3][11]
The proportion of each component in a batch is stated on its Certificate of Analysis.
Evidence for the combination
Methionine, choline and inositol were studied together as "lipotropic factors" in Italian animal and pharmaceutical work of the 1950s.[6][7] A PubMed search found no modern controlled study of the three-component combination, and a 2013 review noted that lipotrope intervention studies in humans are practically non-existent.[1][8] Any benefit of combining them is a research question, not an established effect.
For research use only. Not for human consumption.
Mechanism of Action
How lipotropes are thought to act
Lipotropes are thought to clear fat from the liver mainly by increasing phospholipid synthesis through the transmethylation pathway, which supports the export of triglyceride-rich lipoproteins, and also by enhancing fatty acid beta-oxidation and shifting the expression of lipogenic and oxidative genes.[1]
Each component
Methionine and SAM: SAM is not only a methyl donor but also regulates hepatocyte growth, death and differentiation. Chronic hepatic SAM deficiency can lead to spontaneous steatohepatitis and liver cancer in experimental models.[2]
Choline: in a controlled feeding study, 77% of men and 80% of postmenopausal women deprived of dietary choline developed fatty liver or muscle damage, against 44% of premenopausal women; function returned when choline was added back.[3]
Methionine plus choline: removing both from the diet is one of the most common ways to model steatohepatitis in rodents, producing liver fibrosis within two to four weeks.[4]
Inositol: in rats fed a high-fructose diet, myo-inositol supplementation reduced hepatic expression of the lipogenic genes Fasn and Elovl6, apparently through lower histone acetylation.[5]
Research Applications
Laboratory research applications
Hepatic lipid metabolism: triglyceride accumulation and lipoprotein export in hepatocyte models, with lipotrope-deficient media as comparator.
Methylation and one-carbon metabolism: SAM availability and methylation in cell systems.
Phospholipid synthesis: phosphatidylcholine production and membrane composition.
Gene expression: lipogenic genes such as Fasn and Elovl6.
Related products
MIC is often studied with L-Carnitine, another lipotrope, and with Vitamin B12, the cofactor of methionine synthase. All of these appear together in the multi-component Super Shredder Blend.
MIC Blend is not an approved drug. This product is sold for laboratory research and is not intended for human or veterinary use.
Frequently Asked Questions
What is MIC Blend?
A research mixture of methionine, inositol and choline, three compounds classed as lipotropes because animal studies linked them to clearing fat from the liver.
What does MIC stand for?
Methionine, Inositol and Choline.
What are lipotropes?
Compounds that hasten the removal of fat from the liver or reduce its deposition, mainly by supporting phospholipid synthesis and lipoprotein export. The main ones are choline, betaine, myo-inositol, methionine and carnitine.
Has the MIC combination been studied?
Only in early animal and pharmaceutical work from the 1950s. We found no modern controlled study of the three-component combination, and human intervention studies of lipotropes are practically non-existent.
How is MIC Blend related to Super Shredder Blend?
Super Shredder Blend contains MIC together with L-carnitine, ATP, albuterol and vitamin B12. See Super Shredder Blend.
How should MIC Blend be stored?
Keep the lyophilized powder at −20 °C, protected from light and moisture.
Scientific References
Fardet A, Chardigny JM. Plant-based foods as a source of lipotropes for human nutrition: a survey of in vivo studies. Crit Rev Food Sci Nutr. 2013;53(6):535-90. PubMed
Lu SC, Martínez-Chantar ML, Mato JM. Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease. J Gastroenterol Hepatol. 2006;21 Suppl 3:S61-4. PubMed
Fischer LM, daCosta KA, Kwock L, et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr. 2007;85(5):1275-85. PubMed
Alshawsh MA, Alsalahi A, Alshehade SA, et al. A Comparison of the Gene Expression Profiles of Non-Alcoholic Fatty Liver Disease between Animal Models of a High-Fat Diet and Methionine-Choline-Deficient Diet. Molecules. 2022;27(3):858. PubMed
Shimada M, Hibi M, Ozeki S, et al. Dietary supplementation of myo-inositol for preventing fatty liver disease by altering hepatic epigenetic modifications in the transcribed regions of Fasn and Elovl6. Biomed Res. 2026;47(2):47-53. PubMed
Capretti G, Paglia G. [Lipotropic factors and atherosclerosis; action of methionine, choline and inositol on experimental cholesterol atherosclerosis]. G Clin Med. 1950;31(9):1120-37. PubMed
Maggiorelli E. [Determination of inositol, methionine & choline in liver-protective tablets from the Istituto Chimico Farmaceutico Militare]. Boll Chim Farm. 1958;97(1):28-37. PubMed
PubMed search (October 8, 2026): methionine[ti] AND inositol[ti] AND choline[ti] returns three articles, all from 1950 to 1958; no controlled study of the combination was found. PubMed
Sources are peer-reviewed publications indexed in PubMed and trial registrations on ClinicalTrials.gov. Each citation was checked against its PubMed record.
For research use only. Not for human consumption.
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