Retatrutide
Triple GIP/GLP-1/Glucagon agonist, next generation.
Certificate of Analysis included with every order.
Technical Specifications
| Purity | ≥98% |
|---|---|
| Form | Lyophilized powder |
| Storage | -20°C |
| Molecular Weight | 5466.62 Da |
| Sequence | HXQGTFTSDYSIXLDEEAQAAFIEYLIAGGPSSGAPPPS-NH₂ |
| CAS Number | 2381089-83-2 |
About This Peptide
Retatrutide is a novel triple agonist targeting GIP, GLP-1, and Glucagon receptors simultaneously. This unique tri-agonist mechanism represents a next-generation approach to metabolic research, with studies showing enhanced effects compared to mono or dual agonists.
Research Applications
Triple receptor agonism, comparative metabolic studies, glucagon signaling, next-gen incretin research.
Mechanism of Action
Retatrutide is a novel synthetic peptide that acts as a triple agonist, simultaneously targeting GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors. This tri-agonist mechanism represents the most advanced approach to multi-receptor metabolic modulation, engaging three distinct hormonal pathways that collectively regulate glucose homeostasis, lipid metabolism, energy expenditure, and appetite. The glucagon receptor component adds a thermogenic and lipolytic dimension not present in dual agonists, promoting increased energy expenditure and enhanced hepatic lipid oxidation alongside the insulin-sensitizing and appetite-modulating effects of GIP and GLP-1 activation.
Research Applications
Retatrutide is employed in advanced metabolic research investigating the synergistic effects of tri-receptor agonism compared to mono and dual agonist approaches. Key research applications include comparative efficacy studies against Tirzepatide and Semaglutide, investigation of glucagon-mediated thermogenesis and energy expenditure, hepatic lipid metabolism and steatosis pathway studies, and exploration of multi-receptor pharmacology in metabolic syndrome models. Its unique triple mechanism makes it a valuable tool for researchers studying next-generation incretin therapeutics.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.
