Selank (CAS 129954-34-3; internal code: Selank) is a synthetic heptapeptide of the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, with a molecular weight of 751.87 Da. It was developed as a stable analogue of ...
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Certificate of Analysis included with every order.
Technical Specifications
Purity
≥98%
Form
Lyophilized powder
Storage
-20°C
Molecular Weight
751.87 Da
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
CAS Number
129954-34-3
About This Peptide
Selank (CAS 129954-34-3; internal code: Selank) is a synthetic heptapeptide of the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, with a molecular weight of 751.87 Da. It was developed as a stable analogue of the endogenous tetrapeptide tuftsin (Thr-Lys-Pro-Arg), with the addition of a Pro-Gly-Pro C-terminal extension that substantially increases metabolic stability against peptidase degradation in biological media. Classified within the neuropeptide research space, Selank has attracted considerable scientific attention for its interactions with the central nervous system, particularly in relation to anxiolytic-like and nootropic-like profiles observed in preclinical models.
The compound belongs to a class of regulatory peptides that modulate immune and neuroimmune signaling, tracing its origin to tuftsin, a naturally occurring immunomodulatory tetrapeptide derived from the Fc region of IgG. The structural elaboration in Selank preserves the tuftsin pharmacophore while conferring resistance to rapid enzymatic cleavage, making it a valuable tool compound for studying peptide stability and receptor engagement kinetics in cell-free and cell-based assay systems. Research interest in Selank spans neurochemistry, immunopharmacology, and behavioral neuroscience, as investigators seek to characterize the molecular mechanisms underlying its documented effects on neurotransmitter balance and gene expression profiles in rodent brain tissue.
Selank is supplied by Pepitiva Biolabs as a lyophilized powder of ≥98% purity, suitable for reconstitution in aqueous buffers or DMSO for use across a range of in vitro and preclinical experimental paradigms. Proper storage at −20 °C maintains peptide integrity over extended periods. As with all compounds in this catalog, Selank is intended exclusively for laboratory research purposes and is not formulated for human administration. For research use only. Not for human consumption.
Research Applications
≥98% purity. Lyophilized powder. Storage: -20°C. For research purposes only.
Mechanism of Action
At the mechanistic level, Selank is understood to interact with components of the GABAergic, serotonergic, and dopaminergic systems, based on evidence from preclinical neurochemical studies. Investigations in rodent models have reported that Selank modulates the expression of genes encoding GABAA receptor subunits and influences the activity of monoamine oxidase, contributing to observed shifts in monoamine turnover within limbic brain regions. The compound's tuftsin-derived core also engages specific receptors on immune-competent cells, implicating it in neuroimmune crosstalk research involving cytokine regulation and enkephalin metabolism.
Additionally, Selank has been reported to upregulate brain-derived neurotrophic factor (BDNF) mRNA and protein levels in hippocampal tissue preparations, positioning it as a research probe for studying neurotrophin-dependent signaling cascades, including the TrkB/MAPK/PI3K pathways. Its relative resistance to prolyl endopeptidase and other peptidases makes Selank a useful comparator compound in enzymatic stability assays and in studies designed to correlate peptide half-life with downstream signaling duration in primary neuronal culture systems. For research use only. Not for human consumption.
Research Applications
Selank is employed across a range of preclinical and in vitro research contexts owing to its multifaceted interactions with neurochemical and immunological pathways. Representative research application areas include:
Anxiolytic-like behavioral phenotyping: Use in rodent open-field, elevated plus-maze, and light/dark box paradigms to characterize anxiolytic-like behavioral outcomes and correlate them with neurochemical endpoints.
Neurotransmitter profiling: Investigation of serotonin, dopamine, and GABA metabolite levels in discrete brain regions following acute or subchronic peptide administration in preclinical models.
Neurotrophin signaling studies: Assessment of BDNF, NGF, and TrkB pathway activation in hippocampal or cortical tissue samples and primary neuronal cultures.
Neuroimmune and cytokine modulation research: Examination of interleukin (IL-6, IL-1β, TNF-α) and enkephalin expression changes in immune cell lines and ex vivo brain slice preparations.
Peptidase stability and metabolic assays: Comparative kinetic studies evaluating resistance to prolyl endopeptidase and plasma peptidases, using Selank as a structurally defined reference peptide.
Gene expression profiling: Transcriptomic analysis of GABAergic receptor subunit and monoamine oxidase gene expression in neural tissue following compound exposure.
Storage & Handling Guidelines
Proper storage and handling are essential to maintain peptide integrity and ensure reliable research results. All Pepitiva Biolabs peptides are supplied as lyophilized (freeze-dried) powder, which provides excellent long-term stability when stored correctly. Store lyophilized peptides at -20°C for long-term storage or 2-8°C for short-term use. Once reconstituted, peptide solutions should be stored at 2-8°C and used within the timeframe specified in the product documentation. Always use sterile bacteriostatic water for reconstitution and handle peptides in a clean laboratory environment to prevent contamination. Avoid repeated freeze-thaw cycles, as thermal stress can cause peptide degradation and loss of biological activity.
Quality Control & Certification
This product is manufactured under strict quality control protocols and has been verified through comprehensive analytical testing. Each batch undergoes reverse-phase HPLC analysis for purity determination and electrospray ionization mass spectrometry (ESI-MS) for molecular identity confirmation. A detailed Certificate of Analysis (COA) is available for download, documenting purity percentage, molecular weight verification, appearance, and recommended storage conditions. Pepitiva Biolabs maintains batch-level traceability from synthesis through delivery, ensuring complete transparency and quality assurance for your research.
Frequently Asked Questions
Is this product approved for human use?
No. This product is intended exclusively for in vitro scientific research and laboratory use. It is not approved for human or veterinary use, not intended for diagnostic or therapeutic purposes, and should not be administered to humans or animals under any circumstances.
How do I reconstitute this peptide?
Add sterile bacteriostatic water slowly to the vial, directing the stream against the glass wall rather than directly onto the lyophilized powder. Gently swirl the vial until the powder is fully dissolved — do not shake vigorously. The recommended reconstitution volume depends on your desired concentration. Refer to the product documentation for specific guidance.
Can I get a Certificate of Analysis (COA)?
Yes. A Certificate of Analysis is included with every order and is also available for download from the product page. The COA documents HPLC purity, mass spectrometry identity confirmation, batch number, production date, and storage recommendations.
For research use only. Not for human consumption.
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